G-protein mutations in thyroid tumors.

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Tissue specific G-protein mutations have been found in differentiated thyroid cancer with a higher prevalence in tumors from German than from American patients. Since activating mutations of Gs are principally comparable to chronic TSH stimulation of these tumor-thyrocytes such mutations may predict changes in tumor development and patient prognosis. The fundamental background and recent results of studies on mutational activation of G-proteins are presented.