G-Lactones Upon Double Nucleophilic Additions of Bis(tms)Ketene Acetals to P-systems and Access to New-t owards Cancer Cells Cytotoxic-Endoperoxide Lactones

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Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lac- tones. Unfortunately, in the second case, no further functionalization could be achieved up to now.