Abstract
Background The underlying pathological process in neurodegenerative diseases is associated with altered functional brain organization. Objective To study functional connectivity and its possible behavioral correlates in specific networks in patients with progressive supranuclear palsy (PSP). Methods Whole-brain based “resting-state” fMRI data from 34 PSP patients (Richardson subtype (PSP-RS): n = 22; Parkinsonian subtype (PSP-P): n = 12) and 35 matched healthy controls were subjected to network-based functional connectivity analysis. Results Group comparison between PSP patients and controls revealed significantly decreased functional connectivity (p Conclusion PSP-associated neurodegeneration may be attributed to both, decreased and increased functional connectivity. Decreasing functional connectivity was associated with worse behavioral performance (i.e. cognitive decline, gaze palsy), whereas the pattern of increased functional connectivity may be attributed to adaptive changes.
Published Version
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