Further studies on mechanism of increased capillary permeability in inflammation with the aid of cortisone and ACTH.

Abstract

Summary and ConclusionsCortisone fails to obliterate the spreading reaction caused by hyaluronidase. This substance seems to inhibit at times somewhat the increased capillary permeability induced by 500 to 900 γ of hyaluronidase. An alkaline exudate or leukotaxine induces an increase in the local capillary permeability. Thus, as shown (1,2), the materials are inhibited by adrenal cortical extract or by cortisone. When, however, the exudate is acid in reaction, the local increased capillary permeability is not repressed by either cortisone or by adrenal cortical extract. This is shown to be referable to another factor liberated in the later stages of an acute inflammatory reaction. This substance is concerned with the mechanism of increased capillary permeability in inflammation. This factor is termed “exudin.” Consequently the initial increase in capillary permeability in the development of inflammation is referable to leukotaxine. With the progress of the acute inflammation the pH of the exudate becomes ...