Abstract
The author studied the influence of hi acid and cho sulfate on capillary fragility and permeability of guinea pigs with experimental hemorrhagic diathesis (scurvy, thrombopenic purpura, vascular purpura). Capillary permeability is determined by the concentration of T-1824 in the plasma, and capillary fragility by the Borbely negative pressure method. Capillary permeability and fragility of normal male rats did not increase or decrease by administration of hi acid or cho sulfate. The increase of capillary permeability and fragility in experimental scorbutic guinea pigs was ameliorated by administration of Vitamin C or hi acid. hi acid seemed to inhibit the increase of capillary fragility and permeability in experimental thrombopenic purpuric guinea pigs. Increased capillary fragility of experimental vascular purpura was decreased by administration of hi acid. It seemed that cho sulfate did not ameliorate the increase of capillary permeability and fragility in the experimental hemorragic diathesis. Capillary fragility and permeability were not always parallel each others. In experimental vascular purpura, when the capillory fragility began to increase, the capillary permeability decreased. The contents of acid polysaccharides in blood vessel walls in animals with experimental hemorrhagic diathesis were approximately the same as in normal animals.
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