Abstract
IN AN earlier report (Bogdanove and Halmi, 1953) we presented histo physiologic observations on the pituitary and target glands of rats which had been treated with propylthiouracil (PTU) following the placement of hypothalamic lesions. We were able to confirm Greer’s (1951, 1952) finding that certain hypothalamic lesions may prevent or impair PTUinduced thyroid hyperplasia. However, we never observed actual atrophy of this gland, and the question arose whether similar lesions would produce atrophy and/or decreased function of the thyroid in rats which did not receive any goitrogen. Further, since goitrogen treatment itself results in degranulation of the acidophils and thyrotrophs of the adenohypophysis, the effects of hypothalamic lesions per se on these cell types could not be determined in PTU-treated rats. These unsolved problems prompted the currently reported investigation of the effects of various hypothalamic lesions on rats which did not receive PTU.
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