Abstract
Despite several similarities, the effects of leukocytic endogenous mediator (LEM), a small protein, were further differentiated from bacterial endotoxin, a complex lipopolysaccharide, on the basis of non-identical biological activities. When either substance was administered to normal rats, each produced significant depression in serum zinc and iron concentrations, as well as a flux of amino acids to the liver. However, only LEM produced these effects on host metabolism in rats made tolerant to endotoxin. The effects of LEM and endotoxin on the synthesis and/or release of acute phase serum glubulins were also compared. Endotoxin produced a significant increase in only the α 2-macrofeto-protein of normal rats. By contrast, LEM produced significant increases in all the acute phase serum protein fractions measured in either normal or endotoxin-tolerant rats. The differences and relationships between LEM and endotoxin on host responses are discussed.
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