Abstract
The present study was envisaged to investigate the protective effects of zinc treatment on the activities of various drug metabolizing enzymes, reduced glutathione content, and extent of lipid peroxidation in the livers of male albino rats subjected to long-term carbontetrachloride (CCl 4) toxicity. It was observed that the activities of cytochrome P450, cytochrome b 5. NADPH-cytochrome- e-reductase, and glutathione concentrations were significantly depressed following treatment with CCl 4 for 6 weeks. At the same time, a marked elevation was seen in the extent of NADPH-dependent lipid peroxidation after CCl 4 toxicity. Moreover, significantly depressed concentrations of zinc (Zn 2+) were observed in both serum and liver after 6 weeks of the CCl 4 administration. However, simultaneous zinc treatment to CCl 4-intoxicated rats resulted in significant improvement in the activities of most of the drug metabolizing enzymes as well as the glutathione levels. Similarly, zinc treatment also normalized the CCl 4-induced increase in the extent of NADPH-dependent lipid peroxidation. We conclude that zinc supplementation considerably attenuates the liver injury induced by chronic CCl 4 treatment to rats.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call