Furan誘導體の抗菌力滲透に對する賦形藥としてのGlycol類の態度 第2報

Abstract

In present report the influence of PG (propylene glycol) as a solvent on the penetration of furan derivatives were investigated by the one-dimensional diffusion method. Another experiment was carried out to determine the action of PG as a vehicle strengthening the effect of drugs. The results obtained are as follows : (1) The antibacterial zones in agar tube culture media were markedly increased by the drug (furacin, guanofuracin, parafuracin, paraguanofuracin) when PG was used as a solvent. Staphylococcus aureus Terashima, Diplococcus pneumonia, Bacillus coil, Bacillus typhosus, Bacillus paratyphyphsus A, Bacillus paratyphosus B, Bacillus dysenteria were used as tested strains (See Table 1). (2) The penetrative activity of the furan derivatives in solvents containing various concentration of PG was increased in proportion to PG concentration (Table 2). (3) When PG-furacin solution was exposed to sunlight, its colour turned to red. orange and the antibacterial potency decreased, but this did not-occur if the solution were kept in a dark place (Table 3). (4) The antibacterial activity of furacin was increased in culture media containing increased concentration of PG. The same results were obtained by both the one dimensional diffusion method and the ointment paper disc plate method (Table 5). PG potentiates the antibacterial action of furacin, especially in a lower concentration of the furacin. (5) PG and PEG aid in the furacin soluble and therefore increase its penetration, so they play a role as a drug carrier. Furthermore, the antibacterial activity of furan derivatives especially in a lower concentration is supported by synergism with the antibacterial activity of PG. (6) The penetration of furacin in the gelatin medium was increased by PG and PEG, similar to the situation using agar medium (Table 6).