Furan誘導體の抗菌力滲透に對する賦形藥としてのGlycol類の態度 第1報

Abstract

The experiments were carried out to observe the influence of PG (propylene glycol) and PEG (polyethylene glycol) as vehicles in the penetration of furan derivative ointments (furacin, guanofuracin, parafuracin, paraguanofuracin). Staphylococcus aureus Teracshima, Streptococcus hemolyticus, Diplococcus pneumonia, Bacillus coli, Bacillus typhosus, Bacillus paratyphosus A, Bacillus paratyphosus B and Bacillus dysenteria were tested as strains and the ointment paper disc agar plate method was used. The results obtained were : (1) PG (15%) added to the Unguentum simplex base increased about ten times the penetration of furacin and guanofuracin as compared to the action with only Ung. simplex base. Streptococcus hemolyticus was the only exception, and here the hemolytic activity was increased by the combination with PG (See Table 1 and 2). (2) in studying the penetration of 0.2 % furacin in various bases, PEG was most effective of all. The hydrophilic ointment as well as vaseline bases were weakest in effectiveness (Table 3). (3) The penetrating action of a lower concentration (0.05%) of furacin in the PEG-ointment base was just as effective as a higher concentration (0.2 %) in other bases (Table 4). (4) The penetrations of parafuracin and paraguanofuracin were made more effective by PG and PEG as vehicles (Table 5). (5) The penetration of furacin derivatives was strengthened by PG and PEG in the agar plate culture medium, and the application of these results to the human body was discussed.