Fungal peritonitis in continuous ambulatory peritoneal dialysis patients; a study from South of India

Renukaprasad Yelahanka Suryanarayana,Indhumathi Elumalai,Ramprasad Elumalai,Jayakumar Matcha,Gnanasambandan Ramanathan

doi:10.15171/ipp.2018.15

Renukaprasad Yelahanka Suryanarayana, Indhumathi Elumalai + Show 3 more

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https://doi.org/10.15171/ipp.2018.15

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Journal: Immunopathologia Persa	Publication Date: Feb 17, 2018
License type: cc-by

Abstract

Introduction: Fungal peritonitis is a potential life-threatening complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Objectives: To assess the incidence and outcome of fungal peritonitis in CAPD patients. Patients and Methods: Dialysis records of all end-stage renal disease patients initiated on CAPD treatment were reviewed retrospectively. The study was conducted during January 2010 to December 2016. Mann–Whitney U test was applied for data analysis. Results: Out of 265 dialysis patients, a total of 36 fungal peritonitis were recorded. The incidence rate of fungal peritonitis was 13.6%. The majority of cases was affected by Candida albicans was 41.6%. Moreover, the major cause of end-stage renal disease (ESRD) in our study was diabetic nephropathy in 38.8% of cases. Conclusion: In this study, we found initiation of antifungal therapy and early removal of catheter reduced the mortality rate of fungal peritonitis in CAPD patients.

Highlights

Fungal peritonitis is a potential life-threatening complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD)
We found initiation of antifungal therapy and early removal of catheter, reduced the mortality rate of fungal peritonitis in CAPD patients
For this study a total 265 CAPD patients were included during January 2009 to December 2016

Summary

Introduction

Fungal peritonitis is a potential life-threatening complication for patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Patients and Methods: Dialysis records of all end-stage renal disease patients initiated on CAPD treatment were reviewed retrospectively. The major cause of end-stage renal disease (ESRD) in our study was diabetic nephropathy in 38.8% of cases. Conclusion: In this study, we found initiation of antifungal therapy and early removal of catheter reduced the mortality rate of fungal peritonitis in CAPD patients. The treatment for fungal peritonitis includes fluconazole, amphotericin B and flucytosine, alone or as combination therapy, based on fungal susceptibilities [4]. These conventional antifungal regimens are disappointing, because it usually leads to removal of catheters or may transfer patients to hemodialysis [5]

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