Abstract
To achieve productive infection of a target cell, a virus must express viral proteins, replicate its genome, and assemble infectious particles. For many viruses with RNA genomes, all stages of RNA synthesis are mediated by a virus-encoded RNA-dependent RNA polymerase (RdRP). Viruses with a segmented, double-stranded (ds) RNA genome rely on the encoded RdRP to perform both transcription (dsRNA ® +RNA) and replication (+RNA ® dsRNA). For dsRNA viruses, the RdRP also plays an important role in recognizing and packaging the correct number and constellation of viral RNAs into progeny particles.
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