Abstract
Due to its bioactivity, hydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery. Biodegradable polymers like chitosan and sodium alginate are used as coating materials for ceramic scaffolds. In this work the application of HAp/sodium alginate or chitosan composite materials which provide controlled lidocaine release is discussed. The polymers and lidocaine hydrochloride were incorporated in porous HAp scaffolds. Release of lidocaine hydrochloride was determined using high-performance liquid chromatography (HPLC). Depending on the polymer type used for coating, the crystal structure of the incorporated drug was determined. Drug/bioceramic scaffold/polymer interactions are discussed. The use of polymer coatings sustained lidocaine release from one day up to four days, compared with lidocaine impregnated but uncoated scaffolds.
Highlights
IntroductionHydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery
Due to its bioactivity, hydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery
Scaffolds containing both polymers have significantly improved mechanical strength compared to the pure chitosan or alginatecoated ones [14], in the current research scaffolds were prepared from pure HAp to obtain a better pore structure and coated with chitosan and/or alginate for better cell attachment and controlled drug delivery
Summary
Hydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery. Biodegradable polymers like chitosan and sodium alginate are used as coating materials for ceramic scaffolds. In this work the application of HAp/sodium alginate or chitosan composite materials which provide controlled lidocaine release is discussed. Osteoblast cells seeded on chitosan-alginate scaffolds attach and proliferate better than on pure polymer scaffolds [14] Scaffolds containing both polymers have significantly improved mechanical strength compared to the pure chitosan or alginatecoated ones [14], in the current research scaffolds were prepared from pure HAp to obtain a better pore structure and coated with chitosan and/or alginate for better cell attachment and controlled drug delivery. Lidocaine hydrochloride was used as a model drug It is a commonly used local anesthetic [18] and lidocaine delivery systems based on porous CaP ceramic scaffolds [19] could be promising due to the well-known properties of CaP, and as painkillers after material implantation in vivo [20,21]. The suitability of prepared lidocaine-containing composite materials to act as slow release drug delivery systems was evaluated
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