Abstract
A series of 4 functionalized head-to-head-linked hairpin oligo( N-methylpyrrole) carboxamides with different linkers have been synthesized. Their ability to bind double-stranded DNA and sequence specificity were compared and the apparent K d values of their DNA complexes were determined. These compounds, particularly those with iminodiacetic linkers, revealed a high affinity for DNA ( K d = 4.5–4.8 × 10 −9 M) and sequence specific recognition of 9–10 base pairs.
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