Functionalization of C(sp3)-H bonds adjacent to heterocycles catalyzed by earth abundant transition metals

Abstract

Listen

Translate article

The inception of C–H bond functionalization of common organic substrates has markedly restructured the retrosynthesis of complex molecules. Among the many classes of C–H bonds, those next to a heteroaromatic ring are exceptionally distinct given the fact that their reactivity are controlled either by coordinating the heteroatom to a transition metal catalyst or by the electronic influences of the ring or both during the C–H cleavage process. While evolvements of these reactions promoted by palladium and/or other heavy transition metal catalysts have emerged in numerous reviews and highlights, a comprehensive review on the earth abundant transition metal-mediated approaches has been long awaited. The recent developments on the functionalization of C(sp3)-H bonds adjacent to common heterocyclic moieties by means of earth abundant transition metal catalysts are discussed herein.