Abstract
There are urgent demands for satisfactory antibacterial activity and mechanical properties of bone scaffolds. In this study, zinc oxide whisker (ZnOw) was introduced into calcium sulfate/bioglass scaffolds. Antimicrobial behavior was analyzed using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The results showed that the scaffolds presented a strong antibacterial activity after introducing ZnOw, due to the antibacterial factors released from the degradation of ZnO. Moreover, ZnOw was also found to have a distinct reinforcing effect on mechanical properties. This was ascribed to whisker pull-out, crack bridging, crack deflection, crack branching and other toughening mechanisms. In addition, the cell culture experiments showed that the scaffolds with ZnOw had a good biocompatibility.
Highlights
The lack of antibacterial activity leads to bacterial infection in bone scaffolds [1,2,3]
The results indicated that could provide the scaffolds with remarkable antibacterial activity and gradually enhanced with the
The results indicated that the cells scaffolds withdemonstrating
Summary
The lack of antibacterial activity leads to bacterial infection in bone scaffolds [1,2,3]. ZnO is a novel type of antibacterial agent with strong antibacterial activity, long life expectancy, high safety and low cost [7,8,9,10] It can be employed for developing antibacterial tissue repair materials [11]. ZnO whisker (ZnOw) possesses high strength, modulus and no crystal defects, which has attracted lots of interests as a reinforcing phase in bone scaffolds [16]. ZnOw was incorporated into CaSO4 /bioglass scaffolds and expected enhance simultaneously its antibacterial activity and mechanical properties. Needle-like ZnOw was incorporated into CaSO4/bioglass scaffolds and expected to and micromorphology of scaffolds with different contents of ZnOw were detected through X-ray enhance simultaneously its antibacterial activity and mechanical properties. The cell culture was performed to evaluate adhesion and growth behaviors of osteoblast-like cells on the scaffolds
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