Abstract
Functional Protein Domains Evolve Very Specifically Over Mutations
Highlights
Villin is one of the major cytoskeleton proteins that bind to actin
We have studied the effect of evolutionary alterations in the frequency of occurrence of amino acids on its respective protein structure
Protein structures related to villin HP and SD were downloaded from the Protein Data Bank (PDB)
Summary
Villin is one of the major cytoskeleton proteins that bind to actin. Some of the cell types present in the unorganized brush border in the pancreatic and bile duct have villin, at very low concentration. These cells help in the absorption process exactly similar to functional microvilli of intestine and kidney. Villin belongs to a large class of actin regulating proteins. Regulation of the actin filaments is performed by actin binding proteins. These proteins assist the sequestration of actin monomers, severing and cross-linking of filaments, and cover their ends [3]. The villin is encoded by two mRNAs of dissimilar lengths and surprisingly, the coding region of their cDNAs shows no difference
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