Abstract
AbstractThe fascinating molecular recognition and structural properties make DNA an ideal building block to construct predictable molecular and nanoarchitectures. The molecular assembly interactions guided the construction of predictable and programmable architectures with diverse geometries established in the field of DNA nanotechnology. Some of the concerns, viz., use of long DNA sequences, reproducibility, and cost, limit the practical utility of DNA nanotechnology in its classical form. To overcome these drawbacks, construction of molecular and nanoarchitectures through small functional molecule-templated assembly of short DNA sequences termed as templated DNA nanotechnology or functional DNA nanoarchitectonics has been conceived. The hybrid ensembles and architectures of small molecular templates and short oligonucleotides are formed through the manipulation of conventional and unconventional hydrogen bonding interactions at molecular level. This chapter outlines the small functional molecule-guided methodologies to construct templated molecular and nanoarchitectures of short oligonucleotides with applications ranging from biosensing, imaging, drug, and gene delivery to molecular transfer, microlithography, and device fabrication.KeywordsNucleic AcidFunctional DNA NanoarchitectonicsMolecular ArchitectonicsTemplated Molecular AssemblySmall Functional Molecule
Published Version
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