Abstract
Objective To observe the brain activation performance of bulimia nervosa (BN) patients and to investigate the possible mental mechanisms of BN. Method Seven female BN cases which met criteria of the 3rd version Chinese Criteria of Mental Diseases (CCMD-3) and seven matched health girls were enrolled. All sub-jects were evaluated by Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD-17), and visual ana-logue scale (VAS). Then fulfill functional magnetic resonance imaging (fMRI) examination. It was block-design. Food or non-food pictures selected from International Affective Picture System (IAPS) independently composed the food and non-food task run of fMRI and were showed by computer automatically. Result VAS-food score was higher in BN group than in control (P<0.05). The average intensity activated of BN under food pictures was 7.86 ±0.78 ,average volume activated was 557 voxels; main activation showed in bilateral prefrontal cortex, right cau-date,left amygdala and left cerebellum. The average intensity activated of control group under food pictures was 9.89±1.03, average volume activated was 1340 voxels;main activation showed in bilateral lingual gyrus, precune-us and fight fusiform gyms. Activation under food pictures was significantly different between two groups (P<0.05). Activation under nonfcod pictures did not show difference between two groups. Conclusion Dysfunction of prefrontal-striatum-amygdala-midbrain path may play a critical role in the psycho mechanisms of BN. Key words: Bulimia nervosa; Functional magnetic resonance imaging (fMRI) ; International affective picture system (IAPS)
Published Version
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