Abstract
Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Motor, sensory and cognitive deficits are common following stroke, yet treatment is limited. Along with histological measures, functional outcome in animal models has provided valuable insight to the biological basis and potential rehabilitation efforts of experimental stroke. Developing and using tests that have the ability to identify behavioral deficits is essential to expanding the development of translational therapies. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in rodent models. While there is no perfect test, there are many assessments that are sensitive to detecting the array of impairments, from global to modality specific, after stroke.
Highlights
Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment
Due to the devastating impairments an individual can encounter after suffering a stroke, there is an immediate need for effective treatment
Rodent models have provided valuable insight and understanding of the biological basis and functional outcome of stroke, the selection of individual tests is crucial for the success of translational research
Summary
Stroke is a common cause of permanent disability accompanied by devastating impairments for which there is a pressing need for effective treatment. Identifying behavioral deficits and therapeutic treatments in animal models of stroke is essential for potential translational applications. Rodent models have provided valuable insight and understanding of the biological basis and functional outcome of stroke, the selection of individual tests is crucial for the success of translational research. Behavioral assessments provide the opportunity to monitor pharmaceutical and cell-based treatments by observing functional improvements over time. With this in mind, it is ideal to have animal models that resemble the human model as closely as possible. The present aim of this paper is to review many of the current behavioral tests that assess functional outcome after stoke in the rodent model. Translational approaches aimed at rehabilitation rely on the reliability and validity of animal paradigms and their ability to replicate the human model of stroke
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