Abstract
Enriching the environment to disinhibit the brain and improve cognition
Highlights
Animal models of neurodegenerative and neurodevelopmental disorders showed marked improvement in memory tasks. These effects were often associated with changes in the morphological complexity of pyramidal neurons and with increased neurogenesis in adult subjects when EE was paired with physical exercise (Pang and Hannan, 2013)
The study of EE in this context is highly relevant to public health, as Down syndrome is the most common genetic cause of mental retardation (Roizen and Patterson, 2003)
Initial studies of the mechanisms underlying mental retardation in animal models of Down syndrome focused on the effects of the mutations on hippocampal long term synaptic plasticity (Siarey et al, 1997), a cellular correlate of learning and memory
Summary
A commentary on Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome by Begenisic, T., Spolidoro, M., Braschi, C., Baroncelli, L., Milanese, M., Pietra, G., Fabbri, M. Initial studies of the mechanisms underlying mental retardation in animal models of Down syndrome focused on the effects of the mutations on hippocampal long term synaptic plasticity (Siarey et al, 1997), a cellular correlate of learning and memory.
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