Abstract
Fibroblasts represent a major cell type in the heart and are essential for myocardial function. KATP channels activity has been shown to increase with in vitro differentiation of fibroblasts into myofibroblasts. The hypothesis of this study is that myocardial infarction induces expression of KATP channels in cardiac fibroblasts. Fibroblasts were isolated from left ventricles of normal (CON) and infarcted adult rat hearts. Fibroblasts from infarcted hearts were separately isolated from scar (MI-S) and remote (MI-R) regions.
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