Abstract
We compared measured wave aberrations in pseudophakic eyes implanted with aspheric intraocular lenses (IOLs) with simulated aberrations from numerical ray tracing on customized computer eye models, built using quantitative 3-D OCT-based patient-specific ocular geometry. Experimental and simulated aberrations show high correlation (R = 0.93; p<0.0001) and similarity (RMS for high order aberrations discrepancies within 23.58%). This study shows that full OCT-based pseudophakic custom computer eye models allow understanding the relative contribution of optical geometrical and surgically-related factors to image quality, and are an excellent tool for characterizing and improving cataract surgery.
Highlights
Ocular aberrometry has become a standard tool in research and in the clinic to measure the optical quality of the eye, and its changes with aging [1], accommodation [2, 3] and with surgical interventions (i.e. LASIK [4], intraocular lens (IOL) implantation surgery [5, 6], keratoconus and Intracorneal Ring Segment (ICRS) implantation [7], etc...)
We have presented a customized computer eye model, using individual geometrical data in eyes with intraocular lenses obtained from quantitative 3D anterior segment Optical Coherence Tomography (OCT)
The model predicted the wave aberrations measured in the same eyes with Laser Ray Tracing aberrometry within 0.12 μm accuracy (RMS for astigmatism and high order aberrations, for 5-mm pupils)
Summary
Ocular aberrometry has become a standard tool in research and in the clinic to measure the optical quality of the eye, and its changes with aging [1], accommodation [2, 3] and with surgical interventions (i.e. LASIK [4], intraocular lens (IOL) implantation surgery [5, 6], keratoconus and Intracorneal Ring Segment (ICRS) implantation [7], etc...). There is an increasing number of IOLs available aiming at modifying the patient’s wave aberrations, targeting correction of both refractive error and some high order aberrations (i.e. spherical aberration, such as in aspheric designs, or aiming at the increase of depth-of-focus in presbyopic-correction IOLs) These efforts have not in general been paralleled by a sophistication of the methods to select the most suitable IOL, or to predict the optical quality outcomes. Customized eye models have been shown to accurately reproduce measured high order aberrations, when constructed using the anatomical parameters of individual patients [14, 15] These models are instrumental in understanding the relative contribution of the patient’s corneal topography, IOL design, IOL tilt and decentration, and foveal misalignment, and as platforms to test what optical performance would have resulted if the eye had been implanted with a different IOL design. Quantitative OCT imaging has shown to be a powerful technology to obtain quantitative 3D optical biometry and geometry in individual eyes [16], providing, from a single instrument, all the ocular anterior segment information needed to build a custom pseudophakic model eye
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