Abstract
Cyclin-dependent kinases (CDKs) are the central regulators of the eukaryotic cell cycle, and are conserved across eukaryotes. Their main and well-studied function lies in the regulation and the time-keeping of cell cycle entry and progression. Additionally, more and more non canonical functions of CDKs are being uncovered. One fairly recently discovered role of CDKs is the coordination of carbon and energy metabolism with proliferation. Evidence from different model organisms is accumulating that CDKs can directly and indirectly control fluxes through metabolism, for example by phosphorylating metabolic enzymes. In this mini-review, we summarize the emerging role of CDKs in regulating carbon and energy metabolism and discuss examples in different models from yeast to cancer cells.
Highlights
The eukaryotic cell division cycle is a series of tightly coordinated processes that lead to duplication of DNA and accurate distribution of the genetic material into two daughter cells
cyclin dependent kinases (CDKs) play an important role in coordinating metabolism with the cell cycle and ensuring that the carbon and energy demands of proliferating cells are met
The G1 CDKs and non-cell cycle CDKs are important for the control of metabolism and energy homeostasis on organismal level, even in non-proliferating cells
Summary
The eukaryotic cell division cycle is a series of tightly coordinated processes that lead to duplication of DNA and accurate distribution of the genetic material into two daughter cells.
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