Abstract
Fuel Metabolism Following 3 Days on a Carbohydrate-Free Diet vs. 3 Days of Fasting in Men with Type 2 Diabetes: A Randomized Controlled Crossover Trial
Highlights
In subjects with T2DM, metabolic adaptations to a CHO-free diet and a 72 h fast generally are similar. Both interventions result in a major decrease in circulating glucose concentration
Though not all, results are similar to those reported in subjects without diabetes
A decreased circulating glucose concentration and/or its rate of metabolism likely regulate these adaptations, which occur at a higher fasting glucose concentration in subjects with T2DM
Summary
Our laboratory is interested in the effect of variations in the diet on human physiology and metabolism in subjects with and without type 2 diabetes (T2DM). We are interested in determining several factors related to fuel metabolism. A 72-h fast results in a rapid decrease in circulating glucose to a lower level without a change in non-water body mass. A nutrient-sufficient, carbohydrate (CHO)-free diet has been reported to result in a decrease in glucose, and similar metabolic perturbations. Direct comparisons are not available in subjects without, or with, type 2 diabetes (T2DM)
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