Abstract
In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio < 2 and group B included ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.
Highlights
This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the In Vitro Fertilization (IVF) outcome in young sub-fertile females ≤ 35 years with normal baseline FSH
We collected and analyzed data for 238 patients ≤ 35 years. They were divided according to CD3 FSH/LH ratio into: Group A (201 patients) with FSH/LH ratio < 2 and group B (37 patients) with FSH/LH ratio ≥ 2
There was no significant difference between groups regarding age, body mass index (BMI), duration or type of infertility (Table 1)
Summary
9% of couples are complaining of infertility [1] [2] and approximately 3% of them need in vitro fertilization [IVF] (http://www.asrm.org). Many factors affect the pregnancy outcome, such as the females’ age. It is considered one of the most important factors in IVF success [3]. It was found that young patients have the highest success rate of IVF treatment [4]. Chronological age alone has a limited effect in predicting individual ovarian responses [5]
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