Frontispiece: Enantioselective C−H Bond Functionalization Involving Arene Ruthenium(II) Catalysis

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While p-cymene ruthenium(II)-catalyzed C−H activation has achieved tremendous success in the last two decades, the corresponding enantioselective variant has not been realized until recently and is still in its infancy. In this minireview five strategies to enable arene ruthenium(II)-catalyzed enantioselective C−H activation are summarized: by intramolecular nitrene C−H insertion, chiral transient directing group, chiral carboxylic acid, relay catalysis, and chiral arene ligands. For more details, see the Review by H. Liang and J. Wang (DOI: 10.1002/chem.202202461).