From synthesis to modification - a series of optimization strategies for hydrogels as drug delivery carriers

Abstract

In recent years, hydrogels have been gradually used in the fields of biochemistry and medicine due to their unique structure and properties. Particularly, it plays an important role in the application of tissue stents, coating material and drug delivery systems. However, a major problem with these kinds of application is that they can not satisfy some complex requirements due to their limitations such as poor mechanical properties and lack of specific responsiveness. This study aims to provide a set of feasible modification methods to obtain a hydrogel with better performance in all aspects. The blended hydrogel material and semi-interpenetrating network structure are adopted to enhance the mechanical properties of the product and achieve controllability initially. Moreover, the combination of multi-response hydrogels and 3D printing technology is conducive to manufacturing multilayer smartness hydrogels with high functionality and high controllability in a short period at a low cost. The techniques mentioned in this paper can be used in combination to improve the performance of target products and a set of strategies for realizing smart hydrogel is formed. This paper introduces the current status of advanced hydrogel and the development tendency of this material in the future, which provides a theoretical background for the research direction of hydrogel in drug delivery systems for other scholars.