Abstract
The Mouse Genome Informatics (MGI) database is the community model organism database for the laboratory mouse. MGI supports access to integrated genetic, genomic, and phenotypic data for the mouse. MGI is freely available on the Web at http://www.informatics.jax.org/. The integration of biological data with annotated genome data presents new opportunities for in silico approaches for identifying potential candidate genes associated with regionally localized phenotypes (e.g., Quantitative Trait Loci or QTL). The MGI database contains over 2,550 records for mouse QTL obtained by curation of peer-reviewed scientific literature. Data for each QTL include the phenotypic trait measured and its values in each strain used in a study, the genetic markers that define the genomic region with which the phenotype is associated, the identification of the marker whose location yields the peak statistical score, the publication from which the data were derived, and information about the extent (length) of the QTL region in the genome. The genetic markers used to define QTL were placed on the genome sequence using electronic PCR allowing the evaluation of genetically-defined phenotypes in the context of genes predicted in the genome and the biological attributes (e.g., expression, function, cellular location) of these genes. The QTL data from MGI that have been integrated with the genome are currently accessible via the Ensembl genome browser, the UCSC Genome Browser, and NCBI’s Map Viewer. Supported by NIH grant HG00330.
Published Version
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