From chemical to receptive space

Abstract

Event Abstract Back to Event From chemical to receptive space Jan Sölter1*, Hartwig Spors2, Jan Schumacher2 and Michael Schmuker1 1 FU Berlin, Institut für Biologie, AG Neuroinformatik, Germany 2 Max Planck Institut für Biophysik, Department of Molecular Neurogenetics, Germany In a high throughput screening process we determine the in vivo response of glomeruli in the mouse olfactory bulb to different odors using intrinsic signal optical imaging. On this basis we identify the receptive range of individual glomeruli and predict further activating odors using pattern recognition algorithms: odor molecules are described by physio-chemical descriptors on which Support Vector Machines are trained to distinguish activating and non-activating molecules. The optimal set of descriptors is obtained by using an Evolutionary Algorithm. In an iterative scheme, the hypotheses are validated or falsified by imaging experiments using previously untested odors. In a first iteration for a GFP labeled glomerulus three new potential ligands were identified. Employing the imaging and prediction results of individual glomeruli our goal is to obtain a molecular property map of the olfactory bulb. Keywords: computational neuroscience Conference: Bernstein Conference on Computational Neuroscience, Berlin, Germany, 27 Sep - 1 Oct, 2010. Presentation Type: Poster Abstract Topic: Bernstein Conference on Computational Neuroscience Citation: Sölter J, Spors H, Schumacher J and Schmuker M (2010). From chemical to receptive space. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference on Computational Neuroscience. doi: 10.3389/conf.fncom.2010.51.00111 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Sep 2010; Published Online: 23 Sep 2010. * Correspondence: Dr. Jan Sölter, FU Berlin, Institut für Biologie, AG Neuroinformatik, Berlin, Germany, j.soelter@fu-berlin.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jan Sölter Hartwig Spors Jan Schumacher Michael Schmuker Google Jan Sölter Hartwig Spors Jan Schumacher Michael Schmuker Google Scholar Jan Sölter Hartwig Spors Jan Schumacher Michael Schmuker PubMed Jan Sölter Hartwig Spors Jan Schumacher Michael Schmuker Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.