Abstract
The ability of cells to sense physiological cues and respond by altering their mechanical properties is central for homeostasis. However, our systems-level knowledge of the mechanome–the molecules and pathways that regulate cellular mechanotype–is still emerging. Here I will discuss approaches we are developing to discover novel mechanical regulators using a high-throughput deformability screening platform that we recently invented, with a particular focus on cancer cells. I will also discuss scalable approaches we are developing to generate scaffolds with tunable mechanics and topology that support the proliferation and differentiation of myoblasts in the context of skeletal muscle tissue engineering for cultured meat production.
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