Abstract
From bedside to bench and back again—molecular mechanisms in acute liver failure
Highlights
A major challenge for medical science is the ability to relate findings in cell cultures and animal models back to the patient
acute liver failure (ALF) can be caused by toxins, infections, metabolic and genetic diseases, but irrespective of etiology, ALF is characterized by the massive and confluent loss of functioning hepatocytes
Bantel and Schulze-Osthoff (2012) presented putative mechanisms of hepatocyte cell death, and discussed their relevance in patients with ALF. They propose that the degree of hepatocyte cell death may be a surrogate biomarker of ALF severity, and may be utilized as a predictor of ALF outcomes
Summary
A major challenge for medical science is the ability to relate findings in cell cultures and animal models back to the patient. In their review, Bantel and Schulze-Osthoff (2012) presented putative mechanisms of hepatocyte cell death, and discussed their relevance in patients with ALF. They propose that the degree of hepatocyte cell death may be a surrogate biomarker of ALF severity, and may be utilized as a predictor of ALF outcomes.
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