Abstract
BACKGROUND CONTEXT Currently most cages are made of metal, carbon fiber, polyether ether ketone (PEEK), and bio-absorbable materials. But there are some drawbacks of these materials in terms of biology, biomechanics, etc., mainly in terms of the elastic modulus is too large, poor biocompatibility, and unable to absorb. Allogeneic bone is recognized bone graft material of great osteogenic effect. It has the closest physicochemical properties, structure and activity of protein-based composition of autologous bone. It in rich in a variety of cytokines required for osteogenesis: bone morphogenetic protein-2, vascular endothelial growth factor, core binding factor α1, et. PURPOSE The purpose of this study was to observe the preliminary clinical results of the new allograft cage. STUDY DESIGN/SETTING A retrospective research. PATIENT SAMPLE A total of 152 patients. OUTCOME MEASURES Visual Analogue Scale (VAS) and The Oswestry Disability Index (ODI);Relative intervertebral disc height (RIDH); fusion rate. METHODS From 2012 to 2015, a retrospective review of the first 152 consecutive cases using the new allograft cage in our department was performed. The follow-up ranged from 12 to 36 months (average 18 months). Intraoperative index, clinical outcome and complications were recorded. Radiographs evaluatedrelative intervertebral disc height (RIDH) and fusion rate. RESULTS Between September 2012 and November 2014, total 152 patients surgery using the new allograft cage in our department. A total of 133 c (87.6%) met the inclusion criteria and exclusion criteria. There are 78 males and 55 females. The average follow-up time is 15.2±5.3 months. The main diagnosis are lumbar disc herniation (68/133), Lumbar spinal stenosis (44/133), SpondyloliSthesis (21/133). There are 99 one segments fusion and 33 two segments fusion. Respectively, the average blood loss and operation time is 335.7±214.2ml and 175.2±40.9 minutes in single segments fusion, and 488.3±173.2ml, 335.7±214.2 minutes in double segments fusion. The VAS score decreased significantly from 6.89 ±2.51 preoperatively to 2.72±0.97 in 3 months postoperation. At final follow up, the VAS score is 2.96 ±1.02. There was also a significant improvement of the ODI from 38.3±15.9preoperatively to 14.6±6.3 in 3 months postoperation (P CONCLUSIONS It has the potential ability in promoting fusion rate in relative short time (approximately 6 months) postoperatively. We consider it have good clinical outcomes. However, it is just the preliminary data with a short-term follow up. Long-term follow-up is still needed proved.
Published Version
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