FRI414 Association Between Uterine Leiomyoma Prevalence And Metabolic Syndrome In A Reproductive Aged Latina/Latinx Population

Abstract

Abstract Disclosure: E.L. Ferrell: None. S. Schon: None. L. Jiang: None. F. Valbuena: None. E. Manuel: None. M. Castillo-Mackenzie: None. M. Carnethon: None. D.D. Baird: None. L. Neff: Employee; Self; Eli Lilly & Company. Stock Owner; Self; Eli Lilly & Company. E.E. Marsh: Consulting Fee; Self; Pfizer, Inc., Myovant Sciences. Objectives: Uterine leiomyomas, commonly known as fibroids, are benign tumors in the wall of the uterus that affect approximately 30% of females by the age of 35, and 70% of females by the age of 50. Greater fibroid prevalence has been observed in certain cohorts, with some studies reporting > 85% prevalence in African American women by the age of 50. Increasing evidence suggests that cardiometabolic risk factors contribute to uterine fibroid development. Few studies have assessed either the prevalence of fibroids or their relationship with Metabolic Syndrome (MetS) in the Latina/Latinx population. The objective of this study was to assess the relationship between MetS and fibroid prevalence in a large cohort of Latina/Latinx females. Materials & Methods: This is a cross-sectional analysis of data collected as part of a prospective longitudinal cohort study. The Environment, Leiomyomas, Latinas, and Adiposity Study (ELLAS) follows 707 Latina women over a 4-year period. All participants in this study were between the ages of 21-50 at the time of enrollment. Demographic and baseline information was collected by trained bilingual study staff. Anthropometric measurements were performed, and fasting blood samples were collected. Participants underwent a baseline pelvic ultrasound to assess for the presence of fibroids. MetS diagnosis was based on the 2005 AHA/NHLBI criteria. The association between MetS and fibroids were assessed as categorical variables. Statistical associations were determined using chi-squared tests and logistic regression. Results: Of the 707 participants enrolled in ELLAS, 621 completed the first study visit, and data from the criteria used to diagnose MetS were available from 590 participants. Of those 590, 578 participants completed ultrasound evaluation for fibroids and were included in final analysis. The mean age was 37.4±6.95 years and the mean BMI was 30.1±6.76 kg/m2. A total of 143 participants met criteria for MetS (24.7%). Prevalence of MetS was positively correlated with age. The prevalence of fibroids in this Latina population was 10.7%. There was no statistically significant association between MetS and the presence of fibroids (p value >0.05). Conclusion: Among a large cohort of Latinx females, MetS was not significantly associated with fibroids. The prevalence of fibroids in this population was lower than observed in other populations, suggesting a possible protective factor yet to be identified amongst Latinx females. Given the low prevalence, we were likely underpowered to detect an association. Further research is needed to determine the relationship between cardiovascular, metabolic, and reproductive outcomes in this understudied population. Presentation: Friday, June 16, 2023