FRI0498 HIGH SERUM URIC ACID LEVEL IS ASSOCIATED WITH LOWER INCIDENCE OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN: DATA FROM THE KOREAN NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY

Abstract

Background Osteoporosis is one of the most common morbidities in postmenopausal women. Although serum uric acid (SUA) accounts for about 50% of extracellular antioxidant activity, the role of hyperuricemia in osteoporosis, a condition characterized by high oxidative stress level, has not been investigated in a Nation-wide scale. Objectives The aim of this study is to evaluate an association between SUA and incidence of osteoporosis in postmenopausal women. Methods Data of postmenopausal women from the 2016 Korean National Health and Nutrition Examination Survey were included and retrospectively analyzed. Weighted prevalence and logistic regression analysis were used to determine the incidence of osteoporosis and the effect of SUA on osteoporosis in postmenopausal women. Results One-thousand three-hundred eighty-two (weighted n = 7,064,137) of postmenopausal women were observed. Of these, 401 (29.0%, weighted n = 1,880,586) women developed osteoporosis. Mean age of participants was 63.2 years and mean of SUA was 4.4 mg/dL. The effect of SUA on osteoporosis in postmepausal women was not statistically significant according to univariable logistic regression (OR 0.977, 95% CI 0.855-1.116, p = 0.729). However, SUA was negatively associated with incidence of osteoporosis in postmenopausal women with statistical significance after adjusting for age, obesity, amount of drink, smoking, intake of calcium, rheumatoid arthritis, thyroid diseases, and loss of activity (OR 0.867, 95% CI 0.752-0.999, p = 0.048). Conclusion Our data demonstrated that high SUA is associated with lower incidence of osteoporosis in postmenopausal women. This result suggests a protective role of SUA in metabolic bone diseases.