Abstract
Objective: To find out the frequency of vitamin D deficiency and its relation with glucose parameters and the incidence of gestational diabetes (GDM). Methodology: Gestational diabetes was diagnosed with 75 gram oral glucose tolerance test. Forty-four pregnant women diagnosed with GDM and 78 non-GDM pregnant women were enrolled as case and control group, respectively in this descriptive study. Vitamin D status was classified as deficiency at ≤20 ng/ml for serum 25(OH)D concentrations. Results: The mean ages were 33.4±5.2 (18-44) years and 29.7±4.1 (21-39) years, mean BMI was 30.6±5.9 kg/m² (19.5-46.1) and 25.9±4.4 kg/m2 (16.5-38) in case and control groups, respectively. The frequency of GDM was found 9.38%. The mean serum vitamin D levels in GDM group were significantly lower than in non-GDM subjects (p=0.07). A total of 56.8% of GDM patients were compared with 35.8% of control group which had Vitamin D deficiency and the difference was significant (p= 0.02). There was no significant association between vitamin D levels and fasting glucose, insulin and HbA1c. Vitamin D levels were inversely correlated with clothing style, parathyroid hormone levels, dental problems and muscle cramps. Conclusions: The association of maternal Vitamin D status with the markers of glucose metabolism in pregnancy needs prospective studies.
Highlights
Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy resulting from pregnancy associated insulin resistance and impaired insulin secretion.[1]
We aimed to investigate the frequency of Vitamin D deficiency in pregnant women with gestational diabetes and the relation of Vitamin D levels with the glucose parameters in the presence of gestational diabetes
A total of 413 pregnant women were screened during the study period and 44 pregnant women were diagnosed with GDM
Summary
Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy resulting from pregnancy associated insulin resistance and impaired insulin secretion.[1] Women with GDM are at high risk for gestational or delivery problems and developing diabetes after the delivery.[1]. The studies investigating the impact of Vitamin D status on glucose homeostasis during pregnancy and on the development of gestational diabetes mellitus are limited and the findings are inconsistent.[5,6,7,8,9,10]. We aimed to investigate the frequency of Vitamin D deficiency in pregnant women with gestational diabetes and the relation of Vitamin D levels with the glucose parameters in the presence of gestational diabetes Pak J Med Sci 2013 Vol 29 No 1 www.pjms.com.pk 15 by 1.25(OH)2D.3,4 But the studies investigating the impact of Vitamin D status on glucose homeostasis during pregnancy and on the development of gestational diabetes mellitus are limited and the findings are inconsistent.[5,6,7,8,9,10]
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