Abstract
Oral squamous cell carcinoma is one of the most prevalent diseases worldwide. Acrocentric (D and G groups) satellite associations are known to play important role in the pathogenesis of diseases including cancers. The present work was aimed to study the frequency of satellite association (SA) in human peripheral blood lymphocytes of freshly diagnosed oral squamous cell carcinoma patients. Study was also carried out with in vitro combined treatments of anticancer drugs namely 5- Flurouracil (5-FU) and Cisplatin to note changes in frequency of SA. A Results revealed a significant impact of combined treatments of chemotherapeutic agents on the frequency and pattern of satellite associations.
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