Abstract
Oral squamous cell carcinoma is one of the most prevalent diseases worldwide. Satellite associations are known to play an important role in the pathogenesis of certain diseases including cancer . The present work aimed to study the frequency of satellite association in human peripheral blood lymphocyte culture of freshly diagnosed oral squamous cell carcinoma patients. In vitro anticancer drugs (5-Fluorouracil {5-FU } and Cisplatin) were studied for the frequency of satellite association. Results showed significant impact of chemotherapeutic agents on the frequency of satellite associations of dif ferent groups of acrocentric chromosomes.
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