Abstract
BACKGROUND & OBJECTIVE:
 Peptic ulcer disease (PUD) is one of the common presentations in the medical as well as Gastroenterology clinics and it can end up in various short- and long-term complications among which osteoporosis is highly under rated. Therefore, the present study was designed to determine the frequency of osteoporosis in cases having PUD.
 METHODOLOGY: A cross-sectional study was conducted at the Department of Medicine during 1st January 2020 to 30th June 2020 in Sheikh Zayed Hospital, Lahore. The diagnosed cases of PUD on the basis of history and endoscopic findings with the age range of 20 to 60 years were included. Osteoporosis was labelled as yes, where a T-score of ≤ -2.5 on DEXA scan was noted.
 RESULTS: In this study, there were a total of 139 cases, out of which 75 (53.95%) were males and 64 (46.05%) females. The mean age of the participants was 48.11±9.43 years. Osteoporosis was observed in 14 (10.07%) out of 139 cases. Osteoporosis was seen in 05 (6.67%) males vs 09 (14.06%) females in their respective groups with p= 0.148. Osteoporosis was observed in 4 (5.80%) cases with a duration of PUD up to 2 years and 10 (14.28%) cases with duration more than this with p= 0.096
 CONCLUSION: Osteoporosis is not uncommon in cases with Peptic ulcer disease, and there is no significant association with any of the confounders of this study.
Highlights
Peptic ulcer disease (PUD) is defined as an ulcerative lesion involving the stomach, first part of the duodenum, and lower part of the oesophagus It is one of the salient causes seeking medical attention in outdoor and emergency clinics
Its prevalence in Pakistan is around 9.9 million cases . [1,2] The underlying mechanism of PUD is an imbalance between acid production and protective layers of the body in the mucosal linings
Infections play a pivot role in this, and amongst them, Helicobacter pylori infection has shown a high association with PUD
Summary
Peptic ulcer disease (PUD) is defined as an ulcerative lesion involving the stomach, first part of the duodenum, and lower part of the oesophagus It is one of the salient causes seeking medical attention in outdoor and emergency clinics. Its prevalence is higher in developing countries, due to poor dietary habits and the presence of H- pylori infection. There is a number of risk factors associated with different degrees of association, ranging from H pylori infections to smoking and various dietary associations . The risk factors for osteoporosis include female gender, DM, smoking and decreased intake of calcium, etc. There is always a need for the detection of reversible factors, which can be a peptic ulcer disease. That’s why this study was planned to quantify the burden of osteoporosis in cases of peptic ulcer disease
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