Abstract
Frequency of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphism in patients with venous thromboembolism: Croatian case control study
Highlights
Venous thromboembolic disease is one of the leading causes of morbidity and mortality in the developed world
Heterozygotes for Factor V Leiden polymorphism were more frequent in the group of patients with the thromboembolic disease (16%) than in the control healthy subjects (2.9%), OR = 6.41 (1.81–22.8); P = 0.004
Out of four tested polymorphisms, only the FV Leiden polymorphism showed to be significantly associated with venous thromboembolic disease with an odds ratio OR = 6.41 (1.81–22.76); P = 0.004
Summary
Venous thromboembolic disease is one of the leading causes of morbidity and mortality in the developed world. Venous thromboembolic (VTE) disease is one of the leading causes of mortality and morbidity in developed countries. The incidence of the VTE disease in Caucasian population has not changed during the past twentyve years. In the white American population it occurs in 108/100,000 people a year [2]. The highest incidence is in African population and the lowest in East Asia, Alaska and among the Native Americans [3,4,5,6]. Venous thromboembolic disease occurs as a result of interaction related to a series of risk factors: acquired, environmental and inherited factors [7,8]. Venous thromboembolic disease is highly heritable, and multiple co-inherited genetic risk factors increase the incident risk
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
