Abstract
Different risk factors for venous thromboembolism (VTE) have been identified, including hereditary abnormalities in the mechanisms of coagulation and fibrinolysis. We investigated five genetic polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, TAFI A152G and TAFI T1053C) associated with VTE in individuals from the city of Belem in the Brazilian Amazon who had no history of VTE. No significant difference was found between the observed and expected genotype frequencies for the loci analyzed. We found high frequencies of MTHFR C677T (33.9%) and TAFI T1053C (74%) and low frequencies of FVL (1.6%), FII G20210A (0.8%) and TAFI A152G (0.8%). The FVL G1691A, FII G20210A and MTHFR C677T frequencies were similar to those for European populations and populations of European descent living in the city of Ribeirao Preto in the Brazilian state of Sao Paulo. The frequency of the two TAFI mutations in the Belem individuals was not significantly different from that described for individuals from Ribeirao Preto. We suggest that the risks for VTE in the population of Belem are of the same magnitude as that observed in European populations and in populations with an expressive European contribution.
Highlights
Different risk factors for venous thromboembolism (VTE) have been identified, including hereditary abnormalities in the mechanisms of coagulation and fibrinolysis
We investigated five genetic polymorphisms (FVL G1691A, FII G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T, thrombin-activatable fibrinolysis inhibitor (TAFI) A152G and TAFI T1053C) associated with VTE in individuals from the city of Belém in the Brazilian Amazon who had no history of VTE
The FVL G1691A, FII G20210A and MTHFR C677T frequencies were similar to those for European populations and populations of European descent living in the city of Ribeirão Preto in the Brazilian state of São Paulo
Summary
Prevalence of hereditary risk factors for thrombophilia in Belém, Brazilian Amazon. France Keiko Nascimento Yoshioka, Amélia Góes Araújo, Marli Haydee Tavella, Igor Guerreiro Hamoy and João Farias Guerreiro1 1Universidade Federal do Pará, Centro de Ciências Biológicas, Departamento de Patologia, Laboratório de Genética Humana e Médica, Belém, PA, Brazil. 2 Universidade de São Paulo, Faculdade de Medicina de Ribeirão Ribeirão Preto, Departamento de Medicina Clínica, Laboratório de Hematologia,Ribeirão Preto, SP, Brazil France Keiko Nascimento Yoshioka, Amélia Góes Araújo, Marli Haydee Tavella, Igor Guerreiro Hamoy and João Farias Guerreiro1 1Universidade Federal do Pará, Centro de Ciências Biológicas, Departamento de Patologia, Laboratório de Genética Humana e Médica, Belém, PA, Brazil. 2 Universidade de São Paulo, Faculdade de Medicina de Ribeirão Ribeirão Preto, Departamento de Medicina Clínica, Laboratório de Hematologia,Ribeirão Preto, SP, Brazil
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