Abstract
ObjectivesTo estimate the proportion of positive epidermal growth factor receptor (EGFR) mutations among patients diagnosed with non-small cell lung carcinoma (NSCLC) and T790M at the King Khalid University Hospital (KKUH).MethodsA retrospective cohort study that included all patients that were diagnosed with NSCLC from 2009 to 2017 at KKUH. Data obtained from both electronic and paper medical records and the following information were studied: age, gender, smoking, region, subtype of NSCLC, EGFR mutation test result, treatment, T790M mutation test (if required), comorbidities, metastasis. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS, version 21.0; SPSS Inc., Chicago, IL, USA).ResultsAmong 71 patients with NSCLC 18 cases were identified for EGFR positive mutation and only one case for T790M. Deletion mutation in exon 19 represented 50% of total cases. Moreover, it showed that it is more frequent in males and non-smokers with 61.1% (11) and 66.7% (12), respectively. Majority of the cases were above the age of 60 years by 61.1% (11). The mutations reported highest in those living in Najd with a 44.4% (8) and all the mutated cases were adenocarcinoma. There was no statistical significance in the association between EGFR mutation and disease variables.ConclusionUltimately, we found that the frequency of EGFR and T790M mutations among NSCLC patients at KKUH from 2009 to 2017 was 25.4% and 1.4%, respectively. Moreover, this result was conspicuous among non-smokers.
Highlights
Lung cancer is the second most common cancer among both men and women in the United States and it represents 5% of all cancers in Saudi Arabia [1]
Among 71 patients with non-small cell lung carcinoma (NSCLC) 18 cases were identified for epidermal growth factor receptor (EGFR) positive mutation and only one case for T790M
We found that the frequency of EGFR and T790M mutations among NSCLC patients at King Khalid University Hospital (KKUH) from 2009 to 2017 was 25.4% and 1.4%, respectively
Summary
Lung cancer is the second most common cancer among both men and women in the United States and it represents 5% of all cancers in Saudi Arabia [1]. Non-small cell lung cancer (NSCLC), accounts for 85% of all lung cancer cases and it is the most common primary malignancy leading to synchronous brain metastases [2]. Like other cancers, it is initiated by activating oncogenes or inactivating tumor suppressor genes, which mainly occur through epigenetic changes [3]. It is widely known that smoking is strongly linked to the increased incidence of lung cancer, another risk factor lies in the genes; a mutation of epidermal growth factor receptor (EGFR) or TP53 was reported in patients with NSCLC [4]. Recent studies showed the impact of molecular differentiation on positive EGFR adenocarcinoma with targeted therapy, as it became essential for future therapeutic plans [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
