Abstract
Hodgkin's lymphoma (formerly, Hodgkins disease) is a potentially curable malignancy with distinctive biological behavior and specific clinical characteristics. Limited information is available from developing countries for patients with classical Hodgkin's lymphoma (cHL). Therefore we reviewed the demographical and clinico-hematological profiles along with bone marrow infiltration patterns in adult patients presenting at Liaquat National Hospital and Medical College. In this cross sectional study, 62 adult (≥15 years) patients with cHL were enrolled from January 2010 to December 2014. The mean age was 29.7±13.8 years with a median of 30 years. The male to female ratio was 2:1. B symptoms were present in 72.5% of patients and lymph node enlargement in 85.4%. The frequency of bone marrow infiltration in our cHL patients was found to be 27.4%, the pattern being predominantly focal followed by diffuse. The mean hemoglobin was 9.4±1.9g/dl with a mean MCV of 78.1±7.9 fl, a mean total leukocyte count of 10.9±20.6x109/l and a mean platelet count of 241.6±150.1x109/l. Our analysis shows that clinico-pathological features of cHL in Pakistan are comparable to published data. Peripheral lymphodenopathy associated with B symptoms is the commonest presentation. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease.
Highlights
Classical Hodgkin lymphoma encompasses a group of lymphoid neoplasms with a multifaceted etiology and epidemiology (Roshandel et al, 2011)
Classical Hodgkin’s lymphoma is an uncommon B-cell lymphoid neoplasm which affect around 9000 new patients per annum (Ansell., 2015)
The prognosis of patients with classical Hodgkin lymphoma has been tremendously improved during the last 4 decades. classical Hodgkin’s lymphoma (cHL) is an uncommon entity and very limited studies are available from Pakistan
Summary
Classical Hodgkin lymphoma (cHL) encompasses a group of lymphoid neoplasms with a multifaceted etiology and epidemiology (Roshandel et al, 2011). Hodgkin lymphoma is an uncommon malignancy with an overall incidence of about 2.4-2.8/100,000 individuals yearly with the peak cases reported between 15-29 years of age (Sive and Linch., 2011; Smith et al, 2015; SaderGhorra et al, 2014). Hodgkin’s lymphoma (formerly, Hodgkins disease) is a potentially curable malignancy with distinctive biological behavior and specific clinical characteristics. We reviewed the demographical and clinico-hematological profiles along with bone marrow infiltration patterns in adult patients presenting at Liaquat National Hospital and Medical College. The frequency of bone marrow infiltration in our cHL patients was found to be 27.4%, the pattern being predominantly focal followed by diffuse. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease
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