Abstract
Low maternal vitamin B12 (B12) status has been associated with an increased risk of neural tube defects (NTDs) and insulin resistance. It was estimated that 34 % of NTD cases in Canada may be linked to low B12 status in the era of folic acid fortification. Due to the early effects of B12 status on pregnancy outcome, it is crucial for women to be B‐vitamin adequate before conception. South Asians are one of the most vulnerable ethnic groups for B12 inadequacy and are one of the largest ethnic minorities in Vancouver.The objectives of this study are to assess whether South Asian women of childbearing age are more likely to be marginally B12 deficient than women of European descent in the Metro Vancouver area and to determine whether select demographic, dietary, and genetic determinants increase a woman's risk to be marginally B12 deficient.In a convenience sample of 300 healthy non‐pregnant females (19 – 35 y), B12 status is assessed using serum B12, holotranscobalamin, and plasma methylmalonic acid. Sociodemographic status, supplement use, and usual eating habits are assessed by questionnaires.The frequency of marginal B12 deficiency was estimated to be 16% with a trend for higher frequency in South Asian women. The research outcomes will aid in identifying risk factors of B12 deficiency by ethnicity and contribute to the evaluation of periconceptional supplement recommendations.Grant Funding Source: ‘FNH Vitamin Research Fund’ UBC
Published Version
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