Free radicals: From basic science to medicine: 528 pp., 1993. Price in US: $ 117.00. Price in Germany: DM 148.00

Abstract

Free radicals: Generation and mechanisms of damage.- Trevor Slater, free radical redox chemistry and antioxidants: from NAD+ and vitamin C to CCl4 and vitamin E, to thiols, myoglobin and vitamins A and D.- Regulation of gene expression in adaptation to oxidative stress.- Radiation-induced free radical reactions.- Nitric oxide and related radicals.- Mechanisms of oxidative cell damage.- Lipid peroxidation. An overview.- Lipid peroxidation in dividing cells.- Formation and metabolism of the lipid peroxidation product 4-hydroxynonenal in liver and small intestine.- DNA damage by reactive oxygen species. The role of metals.- Inflammation and a mechanism of hydrogen peroxide cytotoxicity.- Aging.- Free radical theory of aging.- Oxidative stress state in aging and longevity mechanisms.- Maillard reaction and oxidative stress are interrelated stochastic mechanisms of aging.- The glycoxidation: a non enzymatic mechanism of protein aging.- Marker or mechanism: possible pro-oxidant reactions of radical-damaged proteins in aging and atherosclerosis, an age-related disease.- Cancer.- Carcinogenesis and free radicals.- Derangements of cellular metabolism in the pre-malignant syndrome.- Molecular mechanisms of oxidant carcinogenesis.- Involvement of oxy-radicals in cancer cell killing and growth.- Free radicals and active states of oxygen in human cancer due to environmental pollutants: public health optimism and scientific skepticism.- Metabolic disorders.- Hepatotoxicity of experimental hemochromatosis.- Role of inducible cytochrome P450 in the liver toxicity of poly-halogenated aromatic compounds.- CBrCl3 toxicity in isolated rat hepatocytes: survey on reasonable cytotoxic mechanisms.- Evidence for a possible role of lipid peroxidation in experimental liver fibrosis.- Ethanol-inducible cytochrome P450 2E1. regulation, radical formation and toxicological importance.- Free radical-induced impairment of liver glycosylation processes in ethanol intoxication.- Oxidative damage and human alcoholic disease. Experimental and clinical evidence.- Oxidised low density lipoproteins.- Protein peroxides: formation by superoxide-generating systems and during oxidation of low density lipoprotein.- An in vitro approach to the study of inflammatory reactions in atherosclerosis.- Antioxidants.- Antioxidant defenses in eukaryotic cells: an overview.- Electron paramagnetic resonance studies on flavonoid compounds.- Antioxidant mechanisms of vitamin E and beta-carotene.- A nuclear pool of glutathione in hepatocytes.- Phospholipid hydroperoxide glutathione peroxidase is the major selenoperoxidase in nuclei and mitochondria of rat testis.- Medical applications of antioxidants: an update of current problems.- Free radicals and antioxidants in muscular and neurological diseases and disorders.- Pharmaceutical intervention for the prevention of post-ischemic reperfusion injury.- Metal-catalyzed free radical injuries in chilhood: disorders and pharmaceutical intervention.- Effect of antioxidants on oxidative modification of human low density lipoproteins.- Approaches to the therapy of glutathione deficiency.- Utilization of oral glutathione.- Author Index.