Abstract
Free Radical Production Mechanisms.- Radical Mechanisms in Fatty Acid and Lipid Peroxidation.- Lipid Peroxidation by Phagocytes.- Triggering and Regulation of the Free Radical Production by Phagocytes.- Two Structurally Unrelated PAF Antagonists, BN 52021 and BN 52111, Partially Inhibit TNF-Induced Superoxide Release by Human Neutrophils.- Membrane Glycoproteins in Superoxide Release from Neutrophils.- Free Radical Production by the Mitochondrion.- Hemoglobin as a Promotor of Central Nervous System Damage.- Role of Xanthine Oxidase and Granulocytes in Ischemia-Reperfusion Injury.- Evidence for Free Radical Generation in Vivo during Cardiac Ischemia and Reperfusion.- Superoxide Generation by Clastogenic Factors.- Chemistry of Free Radical Effects.- Degradation of Membrane Phospholipids by a Direct Nucleophilic Action of Superoxide Anion.- Mechanisms of Formation of Oxysterols: A General Survey.- Role of Oxygen and of Superoxide Radical in the Mechanisms of Monoelectronic Activation of Various Xenobiotics: A Radiolysis Study.- Methods of Measurements.- Methods of Measuring Lipid Peroxidation in Biological Systems: An Overview.- The Measurement of Superoxide and Superoxide Dismutase by Electron Spin Resonance and Chemiluminescence Assay.- Pentane Measurement, an Index of in Vivo Lipoperoxidation: Applications and Limits of the Method.- Action on Model Systems and Cellular Structures.- Action of Aldehydes Derived from Lipid Peroxidation on Isolated Liver Plasmamembranes.- Carbon Tetrachloride-Induced Oxidative Stress at the Level of Liver Golgi Apparatus: Effect on Lipoproteins Secretion.- Oxidized Lipoproteins and Atherogenesis.- Role of Low Density Lipoprotein Oxidation in Foam Cell Formation.- In Vitro Oxidation of Low Density Lipoproteins.- Paradoxical Effects of Vitamin E: Oxidized Lipoproteins, Prostanoids and the Pathogenesis of Atherosclerosis.- The Role of Oxidative Metabolism and Antioxidants in Low-Density Lipoprotein structure and Metabolism.- A New Model System for Studying the Cytotoxicity of Peroxidized Lipoproteins in Cultured Cells.- Biological Effects.- Molecular Mechanisms of Oxidative Cell Damage.- Decompartmentalized Iron, Microbleeding and Membrane Oxidation.- Mutagenic Effects of Oxidized Lipids.- Biological Effects of Oxysterols.- Mechanisms of Hydroperoxide-Induced Broncho- and Vasoconstriction in the Perfused Rat Lung.- Pathophysiological Relevance of Free Radicals to the Ethanol-Induced Disorders in Membrane Lipids.- Lipid Peroxidation in Experimentally Produced Liver Injury, Liver Tumors and in Liver Regeneration.- Lipid Peroxidation and Cellular Functions: In Vitro Models and Relation to in Vivo Observations.- Biochemical Mechanisms of Oxidant-Induced Cell Injury.- Defence Mechanisms.- Cytochrome P-450 and Vitamin E Free Radical Reductase: Formation of and Protection against Free Radicals.- Free Radical Formation and Antioxidant Protection in Extracellular Fluids.- Quinone Redox Cycling and the Protective Effect of DT Diaphorase.- Vitamin E - Vitamin C Synergistic Effect Towards Peroxyl Radicals: Influence of Dehydro-Ascorbic Acid.- Contributors.- Author Index.
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