Abstract

The influence of 6 weeks of progressive exercise training on free 11-hydroxycorticosteroid (11-OHCS) levels before, during and after standardized bouts of treadmill running was investigated in male mongrel dogs. Chronic tracheostomies and omocervical arterial catheterizations allowed for simultaneous assessment of energy expenditure, 11-OHCS, eosinophil and glucose levels at rest, during running, at exhaustion (rectal temperature of 108 F) and after 30 min of recovery. The mean (N = 7) resting level of plasma 11-OHCS was 1.9±0.4 μg/100 ml. Graded increases in work intensity were accompanied by linear increases in both energy expenditure (V02) and plasma free 11-OHCS levels. While responses were variable for lighter work loads, 11-OHCS levels increased significantly during “heavy” work to 5.3 ±1.5 μg/100 ml. At “exhaustion” a further increase to 8.0 ± 1.7 μg/ 100 ml was observed. No significant correlation was found, however, between the 11-OHCS levels and either the eosinophil counts or the rate of energy...

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