Abstract

In a longitudinal study of an epileptic, serial measurements were made of affect and urinary 17-hydroxycorticosteroid (17-OHCS) levels. During an 8-month period of hospitalization, a rising trend in 17-OHCS level was noted on the day prior to seizure activity and a significantly positive rise on the day of seizure activity. These observations were seen as supporting evidence for the hypothesis that elevated 17-OHCS levels may be associated with a lowered seizure threshold. Depression showed a positive linear correlation with both seizure activity and 17-OHCS levels.

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