Abstract
Natural product research has quickly evolved in the last two decades in which fraction libraries and genetics have been key components. In this article, the construction of fraction libraries from several research institutes is described including examples of successfully isolated compounds from each collection. From our group's fraction library, interesting decalin-containing natural products were obtained, and a selected review of these compound classes is presented. This is followed by a section on genome mining and engineering that tackles the discovery of Diels–Alderases involved in decalin formation, the production of unnatural decalins by genetic manipulation, and examples of the application of synthetic biology in natural product research.
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