Abstract
Inclusion body hepatitis (IBH) is, in some cases, a fatal disease affecting fowl by adenovirus strains which are subdivided into 5 species (A-E). In the current study, we investigated sequences from the Loop L1 region of the hexon gene of sequences of adenovirus field stains 1/A and 11/D isolated from a poultry flock co-infected with IBH and avian reoviruses ARVs. In early 2021, an epidemiologic survey highlighted the coinfection adenoviruses with other viruses (orthoreovirus infection) as being particularly deleterious within the poultry industry. Here, we investigated the Loop L1 HVR1-4 region of the hexon gene with relative synonymous codon usage (RSCU) designation and RSCU inclusive of all the mutations. These are the first results that have been presented on fowl adenovirus species A and D with simultaneous reovirus infection in 38-days old broiler chickens in Poland.
Highlights
In poultry farms, viral coinfections are becoming increasingly frequent
We investigated sequences from the Loop L1 region of the hexon gene of sequences of adenovirus field stains 1/A and 11/D isolated from a poultry flock co-infected with Inclusion body hepatitis (IBH) and avian reoviruses ARVs
Adenovirus infections are often described as coinfections involving viruses such as infectious bursal disease virus (IBDV) [1], avian reoviruses (ARVs) [2], Marek’s disease virus (MDV) [3, 4], and chicken infectious anaemia virus (CIAV) [1, 5,6,7]
Summary
Adenovirus infections are often described as coinfections involving viruses such as infectious bursal disease virus (IBDV) [1], avian reoviruses (ARVs) [2], Marek’s disease virus (MDV) [3, 4], and chicken infectious anaemia virus (CIAV) [1, 5,6,7]. Fowl adenoviruses (FAdVs) are double-stranded DNA viruses of the adenovirus genus of the Adenoviridae family. The different types of adenoviruses (FAdV-1-8a-8b-11) are represented by five species (FAdV-A-E) which frequently exist in poultry flocks [8,9,10,11]. Whilst commonly non-pathogenic, under specific conditions, FAdVs can induce disease and other pathological syndromes/disorders [12]. The clinical outcomes of pathogenic coinfections are usually well evaluated; a clear explanation of the mechanisms shaping the complex interactions that take place between infectious agents is often lacking
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